Giorgi Gogichadze

(Author)

Views and Suppositions about the pathogenesis of CancerPaperback, 21 January 2016

Views and Suppositions about the pathogenesis of Cancer
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Print Length
112 pages
Language
English
Publisher
Disserta Verlag
Date Published
21 Jan 2016
ISBN-10
3959351925
ISBN-13
9783959351928

Description

Primary target for carcinogens are determinants of cellular membranes, but not cell's DNA. On the first stage of carcinogenesis (initiation) two normal somatic cells of one organ or tissue may create dikaryons, but in some cases nonviable polykaryocytes. During the perforation of cellular membranes induced by different carcinogenic agents and factors, the total negative charge of plasma membranes decrease and the cells acquire the capability of closely approaching (adhesion), which frequently, especially upon coincidence of the perforated parts, may serve as a prerequisite to fusion process. After synchronous mitosis or simple mechanical assembly of hetero-or homokaryons nuclei, mononuclear hybrid precancerous cells develop, with a tetraploid set of chromosomes on initial stage of hybridization. In addition to the data evidencing the hybrid origin of a cancer cell, this work attempts to answer some important and still unanswered questions of modern oncology.

Product Details

Author:
Giorgi Gogichadze
Book Format:
Paperback
Country of Origin:
US
Date Published:
21 January 2016
Dimensions:
21.01 x 14.81 x 0.58 cm
ISBN-10:
3959351925
ISBN-13:
9783959351928
Language:
English
Pages:
112
Publisher:
Weight:
140.61 gm

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