The rational scientific approach to face a potentially fatal viral
pandemic with no known effective specific therapies dictate the early
use of all the useful preliminary research evidence with prioritizing
emphasis on safety to avoid making more harm than good in such
situation. We have previously published an evidence-based keys to the
therapeutic challenge associated with the emergence of SARS-CoV-2
pandemic. The aim of this paper is to provide and important updates to
keys to the therapeutic challenge which are hoped to help in cracking
the padlock of SARS-CoV-2.