David Fisher, MD, PhD, and an authoritative panel of academic,
cutting-edge researchers review and summarize the current state of the
field. Describing the broad roles of tumor suppressors from a
perspective based in molecular biology and genetics, the authors detail
the major suppressors and the pathways they regulate, including cell
cycle progression, stress responses, apoptosis, and responses to DNA
damage. Leading-edge and forward-looking, Tumor Suppressor Genes in
Human Cancer illuminates what is currently known of tumor suppressor
genes and their regulation, work that is already beginning to
revolutionize cancer target elucidation, drug discovery, and treatment
design.