Transmethylations and the Central Nervous System (Softcover Reprint of the Original 1st 1978)Paperback - Softcover Reprint of the Original 1st 1978, 23 August 2014

Transmethylations and the Central Nervous System (Softcover Reprint of the Original 1st 1978)
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Part of Series
Monographien Aus Dem Gesamtgebiete der Psychiatrie
Print Length
188 pages
Language
English
Publisher
Springer
Date Published
23 Aug 2014
ISBN-10
3642885187
ISBN-13
9783642885181

Description

V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu- ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina- tion of certain mental diseases came from Harley-Mason (1952), who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par- ticularly that mescaline represented the product of O-methylation of dopamine in posi- tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol- amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla- tion might follow a "deviant" metabolie pathway, and that the accumulation of abnor- mal methylated metabolites endowed with hallucinogenic properties might be responsi- ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata- tonia in experimental animals.

Product Details

Book Edition:
Softcover Reprint of the Original 1st 1978
Book Format:
Paperback
Country of Origin:
NL
Date Published:
23 August 2014
Dimensions:
24.41 x 16.99 x 1.07 cm
ISBN-10:
3642885187
ISBN-13:
9783642885181
Language:
English
Location:
Berlin, Heidelberg
Pages:
188
Publisher:
Springer
Weight:
322.05 gm

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