This book describes recent advances in translational research in breast
cancer and presents emerging applications of this research that promise
to have meaningful impacts on diagnosis and treatment. It introduces
ideas and materials derived from the clinic that have been brought to
"the bench" for basic research, as well as findings that have been
applied back to "the bedside". Detailed attention is devoted to breast
cancer biology and cell signaling pathways and to cancer stem cell and
tumor heterogeneity in breast cancer. Various patient-derived research
models are discussed, and a further focus is the role of biomarkers in
precision medicine for breast cancer patients. Next-generation clinical
research receives detailed attention, addressing the increasingly
important role of big data in breast cancer research and a wide range of
other emerging developments. An entire section is also devoted to the
management of women with high-risk breast cancer. Translational
Research in Breast Cancer will help clinicians and scientists to
optimize their collaboration in order to achieve the common goal of
conquering breast cancer.