Corina Schmidt

(Author)

The Role of Wnt Signalling in the Development of Somites and Neural Crest (2008)Paperback - 2008, 12 June 2008

The Role of Wnt Signalling in the Development of Somites and Neural Crest (2008)
Qty
1
Turbo
Ships in 2 - 3 days
In Stock
Free Delivery
Cash on Delivery
15 Days
Free Returns
Secure Checkout
Buy More, Save More
Part of Series
Advances in Anatomy, Embryology and Cell Biology
Print Length
64 pages
Language
English
Publisher
Springer
Date Published
12 Jun 2008
ISBN-10
3540777261
ISBN-13
9783540777267

Description

1 Introduction 1. 1 Wnts and Development The f amily of Wnt genes consists of at least 19 members in vertebrates. Wnts ha v e multiple roles during normal development and aetiology of diseases (Wodarz and Nusse 1998; Moon et al. 2002, 2004). These genes encode for glycoproteins that are released in the intercellular space, acting as intercellular mediators (Moon et al. 1997). By binding to their special receptors, the Frizzled (Fz) receptors, they are able to activate at least three different pathways: the canonical, the non-canonical and the Ca 2+ pathway (Fig. 1 ). The Wnt family has been subdivided, using functional assays, into at least two subclasses. In Xenopus, Wnt1, Wnt3a and Wnt8 are able to induce axis duplication in embryos, whereas Wnt4, Wnt5a and Wnt11 cannot (Du et al. 1995). Those Wnts that are able to induce axis duplication are thought to act canonically; those who cannot are thought to act non-canonically. In the literature, therefore, some Wnts are called canonical Wnts while others are called n- cano nical Wnts, suggesting that a special Wnt always activates the same signalling pathway. It is unlikely that the specificity dictating cellular responses resides solely in the Wnt ligands because no one has reported sequence or structural motifs in Wnts that predict their activities in these cellular and embryonic assays.

Product Details

Authors:
Corina SchmidtImelda McGonnellSteve AllenKetan Patel
Book Edition:
2008
Book Format:
Paperback
Country of Origin:
DE
Date Published:
12 June 2008
Dimensions:
23.11 x 14.99 x 0.51 cm
ISBN-10:
3540777261
ISBN-13:
9783540777267
Language:
English
Location:
Berlin, Heidelberg
Pages:
64
Publisher:
Weight:
158.76 gm

Related Categories


Need Help?
+971 6 731 0280
support@gzb.ae

About UsContact UsPayment MethodsFAQsShipping PolicyRefund and ReturnTerms of UsePrivacy PolicyCookie Notice

VisaMastercardCash on Delivery

© 2024 White Lion General Trading LLC. All rights reserved.