The GnRH Neuron and its Control examines the developmental biology of
GnRH neurons including their birth in the nasal placode of the early
embryo, perinatal programming, and sexual differentiation, in addition
to the hypothalamic mechanisms that control GnRH neurons in adulthood to
generate pulsatile and surge modes of GnRH secretion throughout the
major life stages including aging. The morphology, electrophysiology,
signal transduction pathways, transcriptional regulators, and genomics
underlying function of the adult GnRH neuron is discussed in detail, as
is the neuroendocrinology and cell biology governing the generation of
both modes of GnRH release.
The book also reviews the neurobiological mechanisms and circuitry
responsible for the modulation of the activity of GnRH neurons by
season, stress, nutrition, and metabolism, and covers the current and
potential therapeutic approaches to regulating GnRH secretion and
action. Filled with newly identified research and classical fundamental
knowledge to GnRH biology, it will provide students, researchers, and
practitioners with an in-depth understanding of reproductive
neuroendocrinology.
This is the fifth volume in the Masterclass in Neuroendocrinology
Series, a co- publication between Wiley and the INF (International
Neuroendocrine Federation) that aims to illustrate highest standards and
encourage the use of the latest technologies in basic and clinical
research and hopes to provide inspiration for further exploration into
the exciting field of neuroendocrinology.
