The discovery of adenoviruses naturally induced a new interest in
viruses of the human upper respiratory tract since previously unknown
viruses infecting this portion of the human body had not been identified
in 20 years, and their unique characteristics stimulated investigations
into the biochemical events essential for replication of animal viruses.
Indeed, the field of molecular virology has evolved during the period
since their dis- covery, and adenoviruses have played a major role in
this development. The exciting discoveries made with adenoviruses have
had such a pro- found effect on knowledge in basic virology, molecular
biology, viral ge- netics, human and animal infections, and cell
transformation that this seemed a propitious time to have some of the
major contributors review this field. This volume pays tribute to the
late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial
discoveries of adenoviruses have tremendously enriched virology. Harold
S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg
Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction
................................... . 5 II. Chemical and Physical
Properties ................... . 6 III. Virus Capsid: Composition and
Organization .......... . 7 A. Hexon
..................................... . 10 B. Penton
.................................... . 12 C. Other Virus Polypeptides
Associated with the Capsid 13 D. Organization of the Capsid
..................... . 14 IV. Virus Core
.................................... . 15 A. Evidence for the Core Shell
..................... . 17 B. Organization of the DNA-Protein Complex
(Nucleoc- sid) ....................................... . 18 C. Tentative
Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the
Adenovirion ......................... . 29 32 References
.......................................... .
