This volume explores the mechanisms of resistance to targeted
therapeutics. The focus is on the cancer cell signaling network,
although other mechanisms of resistance including target mutation, and
new areas of study such as cancer stem cells are included.
Targeted Therapies: Mechanisms of Resistance highlights examples of
changes in the signaling network in response to inhibition of a
signaling event and underscores the importance in having a mechanistic
understanding of the signaling network in cancer for developing
effective targeted cancer therapies. Moreover, cutting edge tools to
analyze the cell signaling network will be discussed. This includes the
leading edge of techniques as well as computational biology and systems
theory. This volume provides the reader with both an overview as well as
a detailed perspective on the mechanisms of resistance to targeted
therapeutics and will be of great value to the oncologist, the
physician-scientist treating patients and the translational scientist
working on any aspect of targeted therapeutics.