Synthesis of Biginelli reaction products using a silica gel supportedPaperback, 10 September 2019

In my work I have focused on the various aspects of Biginelli reaction using a very promising and effective heterogeneous catalyst. The catalyst having acidic property and eco-friendly nature which is derived from thiomaleic anhydride composited with silica gel porous material for three component one-pot Biginelli reactions. Total seven biginellibased reactions were performed and all the products were obtained with good yields. This bronsted acid catalyst works efficiently at room temperature or with some heating without refluxing and high yielding in lesser time. This single step and one-pot synthesis takes almost two hours to complete the reactions. Product separation is simple just by filtration. Very low amount of organic solvent is required to conduct the reactions. Catalyst is characterized by BET analysis. NMR and IRcharacterizations are done with all the seven obtained products. All the reactions progress will be controlled by thin layer chromatography methods and the measurements of melting points of all the dried products.