Volume 12 in this series explores the latest experimental and clinical
uses of stem cells in the treatment of disease and of injuries and
reviews methods for isolating multipotent endothelial-like cells from
human adipose tissue and discusses clinical applications in cell therapy
and regenerative medicine.
The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem
Cells, Dendritic Stem Cells, Regenerative Medicine and General
Applications. The first section includes chapters on histamine in the
neural and cancer stem cell niches and emerging concepts of stem cell
organization in the normal lung and in lung cancer. The section on
Pluripotent Stem Cells includes discussion of the differentiation of
dendritic cells from human induced pluripotent stem cell and the
molecular mechanisms involved in reprogramming human somatic cells to
generate induced pluripotent stem cells. Additional chapters cover the
differentiation of induced pluripotent stem cells into functional
cardiomyocytes, characteristics of satellite cells and multipotent adult
stem cells in the skeletal muscle. The section on Dendritic Stem Cells
explores the critical role of notch signaling in the differentiation and
function of dendrite. Other chapters cover hypertensive emergencies in
children after stem cell transplantation and overcoming the radio
resistance of lung cancer stem cells. The section on Regenerative
Medicine reports on experiments on improved renal revascularization in
pigs using stem cells and phenotypic correction of murine Hemophilia A
using cell-based therapy. The concluding section, General Applications,
discusses such topics as methods in mathematical modeling for stem
cells, as well as molecular and functional characterization of human
adipocytes.
Like its eleven predecessors in the series*,* this volume stands out for
its comprehensive approach, its roster of some 51 expert contributors
representing a dozen different countries and its up-to-date review of
leading-edge technology and methods.
