Presenting contributions by 66 experts representing 13 countries, Volume
10 of the series Stem Cells and Cancer Stem Cells synthesizes current
understanding of the causes, diagnosis, and therapy of major human
diseases and debilitating tissue and organ injuries, using cell-based
treatment. This volume presents contemporary research into generation,
preservation, and uses of stem cells in fighting disease and
tissue/organ injuries.
The contents of the volume are organized into five sections. Mesenchymal
Stem Cells section includes chapters on the use of stem cells in bone
regeneration, studies and trials of stem cells in autoimmune diseases,
and differences between adipose tissue-derived mesenchymal stem cells
and bone marrow-derived mesenchymal stem cells as regulators of immune
response. Induced Pluripotent Stem Cells section offers chapters on drug
discovery using human IPSC-based disease models, and on generation of
antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem
Cells section discusses use of bacterial artificial chromosomes in the
genetic identification of stem cell-derived neural cell types, and use
of moderate low temperature to preserve the stemness of neural stem
cells. The section, Role of Stem Cells in Disease, discusses stem cell
support in high-dose chemotherapy of Non-Hodgkin's Lymphomas; potential
targets for drug resistant leukemic stem cells, bone marrow stem cell
therapies for diabetes mellitus. This section also discusses the use of
stem cells in treating thyroid, breast and bone cancers, hempophilia and
Parkinson's Disease. The section, Stem Cell Transplantation, includes
chapters on reducing fungal infection in allogenic stem cell
transplantation patients, use of Bulsufan/Fludarabine for conditioning
in haematopoietic stem cell transplantation, and interleukin-7 receptor
alpha polymorphisms in allogeneic stem cell transplantation.
The editor, M.A. Hayat, is a Distinguished Professor in the Department
of Biological, Sciences at Kean University, Union, New Jersey, USA.
