The phenomenon known as Leao's spreading depression is investigated in
this collection of ten original articles. New ideas about the
fundamental mechanisms, which focus on the involvement of
polyunsaturated fatty acids and free radicals, are presented. The
relationship of spreading depression with clinical entities such as
migraine, epilepsy, ischemic and protein-deficiency conditions of the
nervous tissue are discussed as well. Studies dealing with the
application of non-invasive techniques to monitor the disease are
included.