William E Schiesser

(Author)

Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R (2019)Hardcover - 2019, 17 June 2019

Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R (2019)
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Print Length
112 pages
Language
English
Publisher
Springer
Date Published
17 Jun 2019
ISBN-10
3030176355
ISBN-13
9783030176358

Description

The focus of this book is a detailed discussion of a dual cancer vaccine (CV)-immune checkpoint inhibitor (ICI) mathematical model formulated as a system of partial differential equations (PDEs) defining the spatiotemporal distribution of cells and biochemicals during tumor growth.

A computer implementation of the model is discussed in detail for the quantitative evaluation of CV-ICI therapy. The coding (programming) consists of a series of routines in R, a quality, open-source scientific computing system that is readily available from the internet. The routines are based on the method of lines (MOL), a general PDE algorithm that can be executed on modest computers within the basic R system. The reader can download and use the routines to confirm the model solutions reported in the book, then experiment with the model by varying the parameters and modifying/extending the equations, and even studying alternative models with the PDE methodology demonstrated by the CV-ICI model.

Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R facilitates the use of the model, and more generally, computer- based analysis of cancer immunotherapy mathematical models, as a step toward the development and quantitative evaluation of the immunotherapy approach to the treatment of cancer.

To download the R routines, please visit: http: //www.lehigh.edu/ wes1/ci_download

Product Details

Author:
William E Schiesser
Book Edition:
2019
Book Format:
Hardcover
Country of Origin:
NL
Date Published:
17 June 2019
Dimensions:
23.39 x 15.6 x 0.79 cm
ISBN-10:
3030176355
ISBN-13:
9783030176358
Language:
English
Location:
Cham
Pages:
112
Publisher:
Weight:
353.8 gm

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