This volume evaluates carcinogenicity to humans of 19 chemicals that are
carcinogenic to the thyroid follicular-cell epithelium in rodents. These
included some so-called "anti-thyroid" drugs (methimazole,
methylthiouracil, propylthiou-racil and thiouracil); some sedatives
(doxylamine succinate and phenobarbital); and some other drugs including
the systemic antifungal antibiotic griseofulvin, the diuretic
spironolactone, and the antibacterial sulfa drugs sulfamethazine and
sulfamethoxazole. Other chemicals are or have been used in agriculture
as pesticides (amitrole, chlordane/heptachlor, hexachlo-robenzene and
toxaphene), in foods and cosmetics (kojic acid), in hair dyes (2
4-diaminoanisole) or as industrial chemicals (N N'-diethylthiourea,
ethylenethiourea and thiourea).