Sanket Shah

(Author)

SMEDDS - A Tool to Explore Oral Bioavailability ProblemsPaperback, 12 April 2012

SMEDDS - A Tool to Explore Oral Bioavailability Problems
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Print Length
140 pages
Language
English
Publisher
LAP Lambert Academic Publishing
Date Published
12 Apr 2012
ISBN-10
3848495317
ISBN-13
9783848495313

Description

As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. Approximately 40% of new drug candidates have poor water solubility and oral delivery of such drugs is frequently associated with implications of low bioavailability, high intra and inter subject variability and therapeutic failure. It is a great challenge to convert these molecules into orally administered formulations with sufficient bioavailability. Among the approaches to improve the oral bioavailability of these molecules, the use of self-emulsified drug delivery systems (SEDDS) has been shown to be reasonably successful.SEDDS is ideally an isotropic mixture of oils and surfactants and sometimes co-solvents. Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, under conditions of gentle agitation provided by digestive motility of stomach and intestine, it spontaneously disperses to form a fine relatively stable o/w emulsion (micro/nano).

Product Details

Authors:
Sanket ShahMansi Shah
Book Format:
Paperback
Country of Origin:
US
Date Published:
12 April 2012
Dimensions:
22.86 x 15.24 x 0.84 cm
ISBN-10:
3848495317
ISBN-13:
9783848495313
Language:
English
Location:
Saarbrucken
Pages:
140
Weight:
213.19 gm

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