This book systemically presents the latest research on renal fibrosis,
covering all the major topics in the field, including the possible
mechanisms, biomarkers, and strategies for prevention and treatment of
chronic kidney disease (CKD). Due to its high prevalence, CKD represents
a huge global economic and social burden. Irrespective of the initial
causes, CKD progresses to end stage kidney disease (ESKD) due to renal
fibrosis, which is characterized by glomerulosclerosis, tubule atrophy
and atresia, and the excessive accumulation of extracellular matrix
(ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult
population living with CKD will need renal replacement therapy at some
point as a result of ESKD. As such, strategies for preventing or slowing
CKD progression to ESKD are of utmost importance, and studies aiming to
understand the mechanisms of renal fibrosis have been the focus of
intensive research. Recently, novel insights into the pathophysiological
processes have furthered our understanding of the pathogenesis of renal
fibrosis, and more importantly, promoted studies on the early diagnosis
and treatment of CKD. This book draws lessons from the extensive,
state-of-the-art research in this field, elaborating the new theories
and new techniques to offer readers a detailed and comprehensive
understanding of renal fibrosis and as well as inspiration for future
research directions.
