This essential volume comprehensively discusses redox-active
therapeutics, focusing particularly on their molecular design,
mechanistic, pharmacological and medicinal aspects. The first section of
the book describes the basic aspects of the chemistry and biology of
redox-active drugs and includes a brief overview of the redox-based
pathways involved in cancer and the medical aspects of redox-active
drugs, assuming little in the way of prior knowledge. Subsequent
sections and chapters describe more specialized aspects of central
nervous system injuries, neurodegenerative diseases, pain, radiation
injury and radioprotection (such as of brain, lungs, head and neck and
erectile function) and neglected diseases (e.g., leishmaniasis). It
encompasses several major classes of redox-active experimental
therapeutics, which include porphyrins, salens, nitrones, and most
notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either
single compounds or formulations with nanomaterials and quantum dots.
Numerous illustrations, tables and figures enhance and complement the
text; extensive references to relevant literature are also included.
Redox-Active Therapeutics is an invaluable addition to Springer's
Oxidative Stress in Applied Basic Research and Clinical Practice
series. It is essential reading for researchers, clinicians and graduate
students interested in understanding and exploring the Redoxome--the
organism redox network--as an emerging frontier in drug design, redox
biology and medicine.
