Modern medicine is undergoing a paradigm shift from a
"one-size-fits-all" strategy to a more precise patient-customized
therapy and medication plan. While the success of precision medicine
relies on the level of pharmacogenomic knowledge, dissecting the genetic
mechanisms of drug response in a sufficient detail requires powerful
computational tools. Quantitative Methods for Precision Medicine:
Pharmacogenomics in Action presents the advanced statistical methods
for mapping pharmacogenetic control by integrating pharmacokinetic and
pharmacodynamic principles of drug-body interactions. Beyond traditional
reductionist-based statistical genetic approaches, statistical
formulization in this book synthesizes elements of multiple disciplines
to infer, visualize, and track how pharmacogenes interact together as an
intricate but well-coordinated system to mediate patient-specific drug
response.
Features:
- Functional and systems mapping models to characterize the genetic
architecture of multiple medication processes
- Statistical methods for analyzing informative missing data in
pharmacogenetic association studies
- Functional graph theory of inferring genetic interaction networks from
association data
- Leveraging the concept of epistasis to capture its bidirectional,
signed and weighted properties
- Modeling gene-induced cell-cell crosstalk and its impact on drug
response
- A graph model of drug-drug interactions in combination therapies
- Critical methodological issues to improve pharmacogenomic research as
the cornerstone of precision medicine
This book is suitable for graduate students and researchers in the
fields of biology, medicine, bioinformatics and drug design and delivery
who are interested in statistical and computational modelling of
biological processes and systems. It may also serve as a major reference
for applied mathematicians, computer scientists, and statisticians who
attempt to develop algorithmic tools for genetic mapping, systems
pharmacogenomics and systems biology. It can be used as both a textbook
and research reference. Professionals in pharmaceutical sectors who
design drugs and clinical doctors who deliver drugs will also find it
useful.
