When STIEVE published his work on male reproductive organs in this
handbook in 1930, a definitive treatment of the morphology of the
accessory sex glands seemed accomplished. Nevertheless, the increasing
bulk of scientific literature published in the last years on this topic
has demonstrated that new methods, e. g., developments in the fields of
electron microscopy, cytochemistry and auto- radiography, pose new
questions. These principally morphological techniques have yielded new
insights into the fine structure and functional organization of these
glands. The stress, however, lay on biochemical questions concerning the
mechanism of hormone action, since the accessory sex glands were
considered to be primary target organs of hormone action, i. e., their
cells bind specific hormones. Besides the basic interest of
endocrinologists, morphologists, and biochemists, several unanswered
questions arose from the practitioners, e. g., urologists, andrologists,
and other clinicians, especially as regards the prostate gland, one of
the organs most affected in elderly men. Thus, the epidemiologic
investigations of the last years proved this very organ to be one of the
most frequent causes of death in elderly men (HANSEN, 1977). The view of
the practi- tioner established a special field of investigation and
effected a shift from morphologic analysis to biochemical or endocrine
aspects. Nevertheless, mor- phology, if tempered by experimental or
concomitant biochemical studies, pro- vides a solid base for tracing the
pathologic events occurring in these organs.