Volume 37 of "Progress in Drug Research" contains seven articles and the
various indexes which facilitate its use and establish the connection
with the previous volumes. While all articles deal with some of the
topical aspects of drug research, the contribution by Al- fred Burger on
"Isosterism and bioisosterism in drug design" is of great value to those
researchers who are engaged in drug design and wish to include isosteric
considerations in establishing a work- ing hypothesis. The remaining six
reviews provide an overview of the work in- volved in the search for new
and better medicines. All these articles contain surveys of the latest
findings in the respective domain. In the 31 years this series has
existed, the Editor has enjoyed the help and advise of many colleagues.
Readers, the authors of the in- dividual reviews and, last but 'not
least, the reviewers have all con- tributed greatly to the success of
PDR. Although many comments received have been favorable, it is
nevertheless also necessary to an- alyze and to reconsider the current
position and the direction of such a series.