Volume 31 of "Progress in Drug Research" contains 13 articles, a sub-
ject index, an index for all articles that have been published so far in
this series of monographs, as well as an author and subject index for
all 31 volumes. The reviews in this volume are particularly concerned
with the therapy of helminth diseases, with pyramidinones as biody-
namic agents, and with quinolones which are of interest in the treat-
ment of infections. For a deeper understanding of the pharmacokinet- ic
actions of modem drugs, the articles on cooperative binding of drug
molecules to DNA, on in vitro models for the study of antibiotic activi-
ties, on inhibitors of the renin-angiotensin system, on GAB A-drug in-
teractions, and on the mechanism of action of anxiolytic drugs provide a
wealth offacts and new findings. The pharmacology of caffeine is re-
viewed from the viewpoint of its role in combination with other phy-
siologically active substances, and the chapter on high resolution nuc-
lear magnetic resonance spectroscopy demonstrates the importance of this
method in the development of new drugs. Finally, the article on light
and dark touches border problems of the therapy of psychic dis- orders.
With these contributions, the authors aim to summarize latest achieve-
ments in important and actual fields of drug research. Researchers who
are actively engaged in the same or in similar fields of research are
sure to benefit from these efforts.