In the first years of the existence of this series of monographs, during
the so-called "Golden Age" of drug research, the majority of the pa-
pers published were mainly concerned with the traditional domains of
drug research, namely chemistry, pharmacology, toxicology and pre-
clinical investigations. The series' aim was to give coverage to impor-
tant areas of research, to introduce new active substances with thera-
peutic potential and to call attention to unsolved problems. This
objective has not changed. The table of contents of the present volume
makes evident, however, that the search for new medicines has become
increasingly complex, and additional, new disciplines have entered the
research arena. The series now includes reviews on bio- chemical,
biological, immunological, physiological and medicinal aspects of drug
research. Researchers actively engaged in the various scientific fields
forming the entity of drug research can benefit from the wealth of
knowledge and experience of the respective authors, and will be assisted
in their endeavour to discover new pharmaceutical agents. Those simply
wanting to keep abreast of new developments in the complex,
multi-discipline science can turn to the "Progress in Drug Research"
volumes as an almost encyclopaedic source of information without having
to consult the innumerable original publications. Volume 32 contains 12
reviews, a subject index, an index for the close to 400 articles
published in the series so far, and an author and titles index for all
32 volumes.