George Tsokos and a panel of authoritative clinicians and researchers
synthesize the latest findings from across cell and molecular biology
with the basic principles of rheumatology to create the first textbook
of molecular rheumatology. These established experts describe the
biochemical mechanisms by which apoptosis, cell signaling, complement,
lipids, and viruses contribute to disease expression, and detail both
immune and nonimmune cell function in rheumatic diseases. Their review
of the major rheumatic diseases integrates the cellular, biochemical,
and molecular biological mechanisms that are important in rheumatic
disease pathogenesis. Path-breaking and illuminating, Principles of
Molecular Rheumatology expands the envelope of clinical understanding to
reveal the biological roots underlying rheumatologic disease, as well as
the nature and roles of the powerful new therapeutics now emerging for
its optimal treatment.