In the 1940s I was struck by reports about many apparently healthy
middle-aged men who dropped dead instantly from heart attacks. The
causes of these sudden deaths were unknown. I was interested to discover
physio-chemical characteristics of individuals with predictive value for
the occurrence of these fatal heart attacks. The discovery ofpreventive
variables would point ways to prevent this disease. In order to find
relationships between mode of life and susceptibility to heart disease
contrasting populations had to be studied. Variety - not a high degree
of homogeneity in culture and habits - must be sought. After exploratory
surveys in countries with supposed differences in dietary patterns,
lifestyle and heart disease rates in the early 1950s, the Seven
Countries Study took off in 1958. This study established relationships
between risk factors and development of heart disease in middle-aged men
in health examined in countries with cultures we demonstrated to
contrast in diet and lifestyle. The results obtained in the Seven
Countries Study from its inception till now are presented in this book
entitled: "Prevention ofcoronary heart disease. Diet, lifestyle and risk
factors in the Seven Countries Study. " Long ago I realized that our
concern should not be restricted to the prevention of coronary heart
disease but should be extended to all diseases and premature death.