Polycystic ovarian disease, or polyfollicular ovarian disease, as Dr.
Fut- terweit prefers to call it, is a disease of uncertain etiology and
for which numerous modes of therapy have been advanced. Understanding of
its pathophysiology should shed light on factors regulating normal
ovarian function; the converse is also true. Recent years have brought
about great understanding of the neuro- endocrine regulation of gonadal
function, as well as of factors in the microenvironment of the ovary
which affect its function. It is also ap- preciated that cases
classified as polycystic ovarian disease actually rep- resent a clinical
and pathological spectrum which may reflect the effects of diverse
etiological factors. In the present volume, Dr. Futterweit presents the
fruits of his long interest in and extensive experience with this
disease. He thoroughly and thoughtfully reviews the vast amount of basic
and clinical information that has been garnered with regard to this
condition over the past decade. The numerous theories that have been
advanced to explain its etiology are presented in balanced fashion, in
addition to a hypothesis, which is well formulated and amenable to
clinical testing. His clinical interests and judgment are well
represented by his presentation of the diverse manifestations of this
condition, the approach to proper diagnosis, and the available
therapeutic options. Patients with this disease represent diagnostic and
therapeutic prob- lems in a situation where manifestations of disease
may lead to major emotional stress.