Parameters such as membrane transport, metabolism and protein
incorporation govern the fate of amino acids in living tissue. Is it
possible to use positron tomography to measure some of them, and what is
their meaning in normal and pathological situations? These questions
have been addressed for a long time and no satisfactory answer has yet
been given.
This book, which derives from an EEC workshop organized in the frame of
the Concerted Action on `PET Investigation of Cellular Regeneration and
Degeneration', held in Lyon in February 1992, gives the present state of
knowledge in this field based on the most recent studies. Contributions
from 24 leading European and American scientists are presented and
discussed in the following four parts:
- biochemistry and animal studies;
- amino acids labelling with positron emittors, quality control and
metabolites measurement;
- kinetic modelling of amino acids transport, metabolism, and protein
incorporation;
- clinical use of amino acids.
This book will aid and interest biochemists, radiochemists,
pharmacologists, neurologists, oncologists and medical imaging
scientists.