Luigi Salmaso

(Author)

Permutation Testing for Isotonic Inference on Association Studies in GeneticsPaperback, 9 July 2011

Permutation Testing for Isotonic Inference on Association Studies in Genetics
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Part of Series
Springerbriefs in Statistics
Part of Series
Springer Briefs in Statistics
Print Length
72 pages
Language
English
Publisher
Springer
Date Published
9 Jul 2011
ISBN-10
3642205836
ISBN-13
9783642205835

Description

The purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but comparisons with other methods will also be drawn, analysing the advantages and disadvantages of each one, particularly with regard to power properties with small sample sizes. In this framework we will work out some nonparametric statistical permutation tests and likelihood-based tests to perform case-control analyses to study allelic association between marker, disease-gene and environmental factors. Permutation tests, in particular, will be extended to multivariate and more complex studies, where we deal with several genes and several alleles together. Furthermore, we show simulations under different assumptions on the genetic model and analyse real data sets by simply studying one locus with the permutation test.

Product Details

Authors:
Luigi SalmasoRosa ArborettiLivio CorainDario Mazzaro
Book Format:
Paperback
Country of Origin:
NL
Date Published:
9 July 2011
Dimensions:
22.86 x 15.49 x 0.51 cm
ISBN-10:
3642205836
ISBN-13:
9783642205835
Language:
English
Location:
Berlin, Heidelberg
Pages:
72
Publisher:
Weight:
136.08 gm

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