Airborne particles when inhaled, can lead to pathological changes in the
respiratory tract. Therefore, toxicological studies on the effects of
inhalable fibers and particles involve an assessment of the
histopathological alterations in the trachea, lungs and the upper
respiratory tract. The pathology of particle and fibre toxicology
depends on the exposure source, duration, concentration and individual
predisposition. Particles such as combustion-derived particles,
engineered nanoparticles, ultrafine particles, silica, asbestos, etc.
can induce an inflammatory response. There may be long term effects of
chronic particle exposure, such as allergic airway inflammation, chronic
obstructive pulmonary disease, fibrosis or neoplasms. The extent of
tissue damage and pulmonary inflammation can be addressed and studied
via pulmonary histopathology as well as diverse histopathological
inflammatory parameters. This book unfolds the innovative aspects of
particle and fibre toxicology which will be crucial for the progress of
this field in the future. It will also provide interesting topics for
research which interested readers can take up. It attempts to assist
those with a goal of delving into toxicology.
