Optimization in Drug Discovery: In Vitro Methods (2014)Hardcover - 2014, 9 November 2013

Optimization in Drug Discovery: In Vitro Methods (2014)
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Part of Series
Methods in Pharmacology and Toxicology
Print Length
597 pages
Language
English
Publisher
Humana
Date Published
9 Nov 2013
ISBN-10
1627037411
ISBN-13
9781627037419

Description

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Product Details

Book Edition:
2014
Book Format:
Hardcover
Country of Origin:
NL
Date Published:
9 November 2013
Dimensions:
25.65 x 18.29 x 3.81 cm
ISBN-10:
1627037411
ISBN-13:
9781627037419
Language:
English
Location:
Totowa, NJ
Pages:
597
Publisher:
Humana
Weight:
1224.7 gm

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