This research book covers the major aspects relating to the use of novel
delivery systems in enhancing both transdermal and intradermal drug
delivery. It provides a review of transdermal and intradermal drug
delivery, including the history of the field and the various methods
employed to produce delivery systems from different materials such as
device design, construction and evaluation, so as to provide a sound
background to the use of novel systems in enhanced delivery
applications.
Furthermore, it presents in-depth analyses of recent developments in
this exponentially growing field, with a focus on microneedle arrays,
needle-free injections, nanoparticulate systems and peptide-carrier-type
systems. It also covers conventional physical enhancement strategies,
such as tape-stripping, sonophoresis, iontophoresis, electroporation and
thermal/suction/laser ablation Discussions about the penetration of the
stratum corneum by the various novel strategies highlight the
importance of the application method. Comprehensive and critical reviews
of transdermal and intradermal delivery research using such systems
focus on the outcomes of in vivoanimal and human studies. The book
includes laboratory, clinical and commercial case studies featuring
safety and patient acceptability studies carried out to date, and
depicts a growing area for use of these novel systems is in intradermal
vaccine delivery. The final chapters review recent patents in this field
and describe the work ongoing in industry.
