Chemotherapeutic Drugs and Oncogenes . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 187 Effect of pM C540 on
c-myc Oncogene in Leukemia . . . . . . . . . . . . . . . . . . . . . . .
. . 188 Down Regulation of c-myc by pMC540 . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189 Effect of
pMC540 on c-myc Proteins . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 192 Tumorigenesis of
pMC540 Treated but Living L1210 Leukemia Cells . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 195 Stimulation ofTopoisomerase
11-Induced Cleavage Sites in a c-myc Oncogene by pMC540 . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 197 Epilogue . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 Index . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 209
=======================PREFACE ========================= his book
describes the discovery of a new technology termed "preactiva- T tion. "
Preactivation is a process by which photoactive compounds are first
exposed to light and thereby converted into new potential drugs that
function independent of light. Basic and preclinical studies have
revealed the dramatic therapeutic potential of some of these compounds.
Thus, preactivation can be used to convert thousands of existing
photoactive compounds into new poten- tial anticancer and antiviral
agents. Although the process of preactivation uses a principle of
photodynamic therapy, the resulting products are strictly
chemotherapeutic in nature, in that they function independent of light.
Once identified, the photoproducts gener- ated via the process of
preactivation can be chemically synthesized. Therapeutic use of light
energy by itself or as an activating agent for light- reactive chemicals
dates back to ancient Egypt. Since those times, one funda- mental
principle of photodynamic therapy has remained constant: light energy is
always applied after the light-reactive chemical or photoactive agent
has arrived at the target.
