Complex metabolic pathway diagrams are a hallmark of many biochemistry
textbooks. But what do they tell us about disease, physiology, cell
signaling, aging, immunity, and gene expression? In a refreshing
approach to the subject of metabolism, Navigating Metabolism provides
a conceptual framework for navigating these pathways, showing how cells
generate energy and synthesize cellular constituents and then further
relating metabolic reactions to molecular, genetic, and signaling
underpinnings. These principles are supported by copious illustrations
that clearly represent metabolic reactions, making them accessible and
relating them to the ways in which cells respond to stimuli to produce
specific biological outcomes. The last few decades have brought
metabolism to the fore, with new results suggesting that it plays a
regulatory role in signaling pathways and gene expression. Viewing
metabolism in this new light provides hope that it may be an avenue for
providing effective
prevention and targeted treatment for many of the diseases that plague
us--cardiovascular, inflammatory disease, diabetes, and cancer. Authored
by Navdeep Chandel, a leading investigator in the field, Navigating
Metabolism is the perfect introduction to this modern view of metabolic
studies.
