Genetic polymorphisms result from common, often benign mutations;
however, some are considered markers of susceptibility to certain
multifactorial conditions. This is the case for 5,10-methylene
tetrahydrofolate reductase (MTHFR); a key enzyme in folate metabolism.
Its role in the risk of acute lymphoblastic leukemia(ALL); the most
common form of pediatric cancers; has generated significant
interest.Thus, our research work focused on exploring, through an
updated meta-analysis, the involvement of MTHFR polymorphisms in
susceptibility to FAL.It is possible that MTHFR variants contribute only
modestly to the emergence of LAL, but it is also possible that their
interactions with other factors could elucidate the cause of this
complex pathology.Thus, analysis of these polymorphisms will promote
nutrigenetics as long as the gene complexity and metabolic activities of
MTHFR are taken into consideration.