As the drug discovery process shifts more and more toward specifically
targeting pathways and molecules, model systems continue to increase in
importance, and the mouse, with its versatility, ease of use, and
remarkable similarity to the human genome, has clearly risen to the
forefront of animal model studies. In Mouse Models for Drug Discovery:
Methods and Protocols, experts in the field present some background for
those less familiar with mice as experimental model platforms as well as
a collection of techniques involving general methods as well as specific
disease topics such as type 1 and 2 diabetes, cardiovascular disease,
arthritis, skin disorders, cancer, the use of behavioral models for
depression and anxiety, neurodegenerative diseases, neuromuscular
diseases, and infectious diseases. Written in the highly successful
Methods in Molecular Biology(TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible laboratory
protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods
and Protocols will stimulate those not familiar with the power of the
mouse and its potential for the drug discovery process, and it will
encourage the development of new models and new ways to utilize existing
models in order to further the use of this dynamic animal in this vital
field.
