Explains why modern supercritical fluid chromatography (SFC) is the
leading "green" analytical and purification separations technology.
Modern supercritical fluid chromatography (SFC) is the leading method
used to analyze and purify chiral and achiral chemical compounds, many
of which are pharmaceuticals, pharmaceutical candidates, and natural
products including cannabis-related compounds. This book covers current
SFC instrumentation as it relates to greater robustness, better
reproducibility, and increased analytical sensitivity.
Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing
Mobile Phases covers the history, instrumentation, method development
and applications of SFC. The authors provided readers with an overview
of analytical and preparative SFC equipment, stationary phases, and
mobile phase choices. Topics covered include: Milestones of
Supercritical Fluid Chromatography; Physical Properties of Supercritical
Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method
Development; Chiral SFC Method Development; and Preparative Scale SFC.
The book also includes highlights of modern applications of SFC in the
final chapters--namely pharmaceuticals, consumer products, foods,
polymers, petroleum-related mixtures, and cannabis--and discusses the
future of SFC.
- Provides a clear explanation of the physical and chemical properties
of supercritical fluids, which gives the reader a better understanding
of the basis for improved performance in SFC compared to HPLC and GC
- Describes the advantages of SFC as a green alternative to HPLC and GC
for the analysis of both polar, water-soluble, and non-polar analytes
- Details both achiral and chiral SFC method development, including
modifiers, additives, the impact of temperature and pressure, and
stationary phase choices
- Details why SFC is the premier modern preparative chromatographic
technique used to purify components of mixtures for subsequent uses,
both from performance and economic perspectives
- Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and
SFC-ELSD (evaporative light scattering detection)
- Describes the application of SFC to numerous high-value application
areas
Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing
Mobile Phases will be of great interest to professionals, students, and
professors involved in analytical, bioanalytical, separations science,
medicinal, petroleum, and environmental chemistries. It will also appeal
to pharmaceutical scientists, natural-product scientists, food and
consumer-products scientists, chemical engineers, and managers in these
areas.