Lei Zhi Chen

(Author)

Modelling and Optimization of Biotechnological Processes: Artificial Intelligence ApproachesPaperback, 18 November 2010

Modelling and Optimization of Biotechnological Processes: Artificial Intelligence Approaches
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Part of Series
Studies in Computational Intelligence
Print Length
123 pages
Language
English
Publisher
Springer
Date Published
18 Nov 2010
ISBN-10
3642067921
ISBN-13
9783642067921

Description

Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods, inparticular, geneticalgorithmsandneuralnetworks, for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological process

Product Details

Authors:
Lei Zhi ChenSing Kiong NguangXiao Dong Chen
Book Format:
Paperback
Country of Origin:
NL
Date Published:
18 November 2010
Dimensions:
23.39 x 15.6 x 0.71 cm
ISBN-10:
3642067921
ISBN-13:
9783642067921
Language:
English
Location:
Berlin, Heidelberg
Pages:
123
Publisher:
Weight:
195.04 gm

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