The state of the art in Biopharmaceutics, Pharmacokinetics, and
Pharmacodynamics Modeling is presented in this new second edition book.
It shows how advanced physical and mathematical methods can expand
classical models in order to cover heterogeneous drug-biological
processes and therapeutic effects in the body.
The book is divided into four parts; the first deals with the
fundamental principles of fractals, diffusion and nonlinear dynamics;
the second with drug dissolution, release, and absorption; the third
with epirical, compartmental, and stochastic pharmacokinetic models,
with two new chapters, one on fractional pharmacokinetics and one on
bioequivalence; and the fourth mainly with classical and nonclassical
aspects of pharmacodynamics. The classical models that have relevance
and application to these sciences are also considered throughout. This
second edition has new information on reaction limited models of
dissolution, non binary biopharmaceutic classification system, time
varying models, and interface models. Many examples are used to
illustrate the intrinsic complexity of drug administration related
phenomena in the human, justifying the use of advanced modeling methods.
This book will appeal to graduate students and researchers in
pharmacology, pharmaceutical sciences, bioengineering, and physiology.
Reviews of the first edition:
"This book presents a novel modelling approach to biopharmaceutics,
pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art
volume will be helpful to students and researchers in pharmacology,
bioengineering, and physiology. This book is a must for pharmaceutical
researchers to keep up with recent developments in this field." (P. R.
Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)
"These authors are the unique (or sole) contributors in this area that
are working on these questions and bring a special expertise to the
field that is now being recognized as essential to understanding
biological system and kinetic/dynamic characteristics in drug
development...This text is an essential primer for those who would
envision the incorporation of heterogeneous approaches to systems where
homogeneous approaches are not sufficient to describe the system."
(Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
