Panos Macheras

(Author)

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics: Homogeneous and Heterogeneous Approaches (Softcover Reprint of the Original 2nd 2Paperback - Softcover Reprint of the Original 2nd 2016, 22 April 2018

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics: Homogeneous and Heterogeneous Approaches (Softcover Reprint of the Original 2nd 2
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Part of Series
Interdisciplinary Applied Mathematics
Print Length
483 pages
Language
English
Publisher
Springer
Date Published
22 Apr 2018
ISBN-10
3319801813
ISBN-13
9783319801810

Description

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.

The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.

Reviews of the first edition:

"This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)

"These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)

Product Details

Authors:
Panos MacherasAthanassios Iliadis
Book Edition:
Softcover Reprint of the Original 2nd 2016
Book Format:
Paperback
Country of Origin:
NL
Date Published:
22 April 2018
Dimensions:
23.39 x 15.6 x 2.59 cm
ISBN-10:
3319801813
ISBN-13:
9783319801810
Language:
English
Location:
Cham
Pages:
483
Publisher:
Weight:
703.07 gm

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