Metabotropic glutamate receptors (mGluRs) are members of the group C
family of G-protein-coupled receptors. Eight different mGlu subtypes
have been identified and classified into three groups based on amino
acid sequence similarity, agonist pharmacology, and the signal
transduction pathways to which they couple. They perform a variety of
functions in the central and peripheral nervous systems, being involved
in learning, memory, anxiety, and the perception of pain. They are found
in pre- and postsynaptic neurons in synapses of the hippocampus,
cerebellum, and cerebral cortex, as well as other parts of the bain and
peripheral tissues. This volume will focus on the latest research in the
role of Group I mGluRs in health and disease.
