Authors and Co-Authors of Volume 4 Preface Contents of Volume 1, 2, and
3 PART I. COLORECTAL CANCER 1. INTRODUCTION: COLORECTAL CANCER M.A.
Hayat INTRODUCTION Screening for Colorectal Cancer Treatment Rectal
Cancer REFERENCES A. Diagnosis 2. POORLY DIFFERENTIATED COLORECTAL
ADENOCARCINOMA: (METHODOLOGY) Seiichi Shinji, Zenya Naito, Toshiyuki
Ishiwata, Yoko Matsuda, Tomoko Seya, and Takashi Tajiri INTRODUCTION
HISTOPATHOLOGY IMMUNOHISTOCHEMISTRY FOR DIFFERENTIAL DIAGNOSIS
IMMUNOHISTOCHEMISTRY FOR MALIGNANT CHARACATERISTICS OF POORLY
DIFFERENTIATED ADENOCARCINOMA IN SITU HYBRIDIZATION FOR MALIGNANT
CHARACTERISTICS OF POORLY DIFFERENTIATED ADENOCARCINOMA THERAPY
REFERENCES 3. COLORECTAL CANCER: IMMUNOHISTOCHEMICAL; DIAGNOSIS WITH
HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K Ayham Alnabulsi, Brian
Carpenter, Colin Telfer, and Graeme I. Murray INTRODUCTION BIOMARKERS
Approved Biomarkers - Problems Biomarkers of Colorectal Cancer Demand
for Colorectal Biomarkers COLORECTAL BIOMARKER HETEROGENEOUS NUCLEAR
RIBONUCLEOPROTEIN K Methodology 2D Gel Electrophoresis (2DGE)
Semiquantitative Reverse Transcription-Polymerase Chain Reaction
Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein K
Immunohistochemistry (IHC) RESULTS DISCUSSION FUTURE DIRECTION
REFERENCES 4. METASTASES AND RECURRENCE OF COLORECTAL CANCER: DIAGNOSTIC
ROLE OF IMMUNOSCINTIGRAPHY Vladimir Obradovic and Vera Artiko
INTRODUCTION GENERAL CONSIDERATIONS Radiopharmaceuticals Imaging Systems
and Techniques IMMUNOSCINTIGRAPHIC METHODS USED FOR DIAGNOSTICS OF
COLORECTAL CANCER Immunoscintigraphy Based onRadiopharmaceuticals
Labeled with Radioiodines Immunoscintigraphy Based on
Radiopharmaceuticals Labeled with 111In Immunoscintigraphy Based on
Radiopharmaceuticals Labeled with 99mTc Comparison of Diagnostic Values
of Different Radiopharmaceuticals Immunoscintigraphy and Positron
Emission Tomography Radioimmunoguided Surgery CONCLUSION REFERENCES 5.
COLORECTAL CANCER DIAGNOSIS USING DNA LEVELS IN BLOOD AND STOOL Emanuela
Flamini, Daniele Calistri, Laura Mercatali, Claudia Rengucci and Dino
Amadori INTRODUCTION AVAILABLE TESTS AND THEIR COST BENEFITS Fecal
Occult Blood Test Flexible Sigmoidoscopy Colonoscopy Barium Enema with
Air Contrast Virtual Colonoscopy MOLECULAR MARKERS AND THEIR COST
BENEFITS FREE CIRCULATING DNA IN BLOOD Biological Mechanisms of Free
Circulating DNA Release Methodological Aspects of Free Circulating DNA
Sources and Influence of Pre-Analytical Factors Isolation and
Quantification Free Circulating DNA Levels in Colorectal Cancer
Diagnosis INTEGRITY OF GENOMIC EXTRACTED DNA FROM STOOL Analysis of Long
Fragment DNA in Stool Advantages and Technical Problems CONCLUSIONS
REFERENCES 6. COLORECTAL CARCINOMA: IDENTIFICATION OF microRNAs USING
REAL-TIME POLYMERASE CHAIN REACTION Eva Bandres, Nerea Bitarte, Natalia
Ramirez, Ruth Zarate, and Jesus Garcia-Foncillas INTRODUCTION GENOMICS
OF microRNA microRNA BIOGENESIS AND FUNCTION EVIDENCE FOR THE
INVOLVEMENT OF microRNA IN CANCER REGULATION OF microRNA EXPRESSION
IDENTIFICATION OF microRNA TARGETS: BIOINFORMATIC AND FUNCTIONAL TOOLS
TECHNOLOGY TO QUANTIFY microRNAs EXPERIMENTAL WORKFLOW FOR microRNA
EXPRESSION BY REAL- TIME POLYMERASE CHAIN REACTION IDENTIFICATION OF
DIFFERENTIALLY EXPRESSED microRNA IN COLORECTAL CANCER USING REAL-TIME
POLYMERASE CHAIN REACTION Q
