This book describes the evolution of ideas relating to the mechanism of
muscular contraction since the discovery of sliding filaments in 1954.
An amazing variety of experimental techniques have been employed to
investigate the mechanism of muscular contraction and relaxation. Some
background of these various techniques is presented in order to gain a
fuller appreciation of their strengths and weaknesses. Controversies in
the muscle field are discussed along with some missed opportunities and
false trails.
The pathway to ATP and the high energy phosphate bond will be discussed,
as well as the discovery of myosin, contraction coupling and the
emergence of cell and molecular biology in the muscle field. Numerous
figures from original papers are also included for readers to see the
data that led to important conclusions.
This book is published on behalf of the American Physiological Society
by Springer. Access to APS books published with Springer is free to APS
members.