Combining experts from the medical and materials sciences, the Institute
considered current concepts in medical and materials sciences as they
relate to implantable prostheses in orthopedic surgical practice. The
syllabus included theory and applications of materials properties,
physiological function, and host response to metal and non-metal
materials. Total hip prostheses are the most common orthopedic device
implanted today involved in over 200,000 operations. Failures occur at
the rate of 10 -40 at to 10 years. Failures are due to loosening,
infection, fracture of femoral components, or destruction of the pe 1 vi
c components .' All these, and other problems related to the
implantation of the devices, the surgical procedures, and device
pathology, were. discussed in light of current, as well as, emerging
technologies and scientific knowledge. Repeatedly, scientists designing
prostheses became aware of a lack of understanding of physiological
phenomena associated with biocompatibility; the interchange among
practising physicians, basic scientists, and pathologists at this
Institute was appreciated. We thank all the contributors and
participants for their effort. Thanks are also due to the personnel of
the Scientific Affairs Division of NATO. The daily routines of running
the Institute were greatly facilitated by the efforts of Pedro Cuevas,
M.D, Jose Gutierrez Diaz, M.D, and Dr. Hanita Kossowsky. The devoted
help of Nir Kossovsky, M.D, in setting the conference and in editing
this book, is sincerely appreci ated.