Mast Cells, Mediators and Disease (Softcover Reprint of the Original 1st 1988)Paperback - Softcover Reprint of the Original 1st 1988, 26 September 2011

Mast Cells, Mediators and Disease (Softcover Reprint of the Original 1st 1988)
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Part of Series
Immunology and Medicine
Print Length
288 pages
Language
English
Publisher
Springer
Date Published
26 Sep 2011
ISBN-10
9401070725
ISBN-13
9789401070720

Description

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain- ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta- chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana- phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.

Product Details

Book Edition:
Softcover Reprint of the Original 1st 1988
Book Format:
Paperback
Country of Origin:
NL
Date Published:
26 September 2011
Dimensions:
23.39 x 15.6 x 1.63 cm
ISBN-10:
9401070725
ISBN-13:
9789401070720
Language:
English
Location:
Dordrecht
Pages:
288
Publisher:
Springer
Weight:
426.38 gm

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