In response to persistent donor organ shortages, organs from marginal
donors, such as expanded criteria donors (ECD) and donation after
cardiac death (DCD) donors, are now accepted and have been successfully
transplanted, reducing the waiting times for transplantation. Especially
in Japan, transplantation of DCD kidneys has a relatively long history
because of the difficulty or lack of national consensus in accepting
brain death, which has made it possible to accumulate considerable
clinical experience. Thus, the current organ shortage has stimulated
interest in the use of marginal donors for transplantation. On the other
hand, however, it is known that these organs have a high rate of delayed
graft function and a more complicated postoperative course. These
drawbacks have created the greatest clinical challenge in
transplantation to date because of the current shortage and limitations
of donors using ECD and DCD.
This book, prepared by distinguished authorities in their fields, is
intended for clinicians and researchers. It highlights the use of
marginal donors as a comparatively novel source of transplantation
organs and provides a thorough overview of marginal donors from their
historical origins to recent clinical applications, including the
state-of-the-art science of organ/donor management, procurement, and
preservation. Also provided is valuable information on ABO-incompatible
donors which extend the availability of donor sources. Each chapter
offers an individual analysis of the optimal requirements for the safe
management and preservation of organs, including the heart, lung, liver,
kidney, pancreas, and pancreatic islets.
