The proposed book will act as a guide for scientists and clinicians to
the unique information that MRS can provide. It will be a comprehensive
overview of clinical and pre-clinical MRS applications and potential
clinical utility of MRS biomarkers in degenerative brain diseases from
leading experts in the field. MRS has proven to be a powerful
complementary tool to MRI for the diagnosis and monitoring of disease
progression and response to treatment because it can detect changes in
cell density, cell type, and biochemical composition, not just
structural changes. As the population in the developed world continues
to age, neuroimaging for diagnosis, prognosis, and therapy monitoring of
neurodegenerative diseases becomes increasingly important and there has
been a recent surge of clinical and pre-clinical applications of MRS
indicating that this technique can provide robust and non-invasive
biomarkers of degeneration.