To produce a comprehensive overview of macrophages and related cell
types in a short review volume is an impossible task. When I selected
the topics to be included, some equally important areas were omitted by
necessity, and for this I apologize. My choices have been somewhat
eclectic, touching subjects of personal interest (such as osteoclast
biology and macrophage electrophysiology) or of current fashion (apopto-
sis, antigen processing, cell adhesion molecules). The book has also had
to encompass areas of a more general flavor to provide balance for the
general reader (such as reviews of macrophage development,
heterogeneity, and function, and of the surface molecules expressed by
macrophages). I thank all the authors for their prompt sub- missions;
all have been of high quality, and my editorial tasks, thankfully, have
been minimal. Michael A. Horton London, United Kingdom ix Contents
Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on
Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2.
The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane
Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to
Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected
Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . .
. . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix
Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.
3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . .
. . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of
Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . .
. .
