9. REFERENCES 90 CHAPTER 9: OPPORTUNITIES FOR REPLACEMENT, REDUCTION
AND REFINEMENT: HUMAN VIRAL VACCINES 93 1. INTRODUCTION 93 2. TESTS FOR
EXTRANEOUS MICROORGANISMS 94 3. MUMPS VACCINE . . . 94 4. HEPATITIS B
VACCINE 95 4. 1. Test for freedom from live hepatitis virus 95 4. 2.
Potency test 95 5. INFLUENZA VACCINE 96 5. 1. Potency test 96 5. 2.
Abnormal-toxicity test 96 6. MEASLES VACCINE. . . . . 96 6. 1. Tests for
extraneous agents 97 6. 1. 1. Test for Mycobacterium tuberculosis 97
6. 1. 2. Test for extraneous viruses 97 6. 2. Abnormal-toxicity test 98
7. POLIOMYELITIS VACCINE. . . 99 7. A. Inactivated poliomyelitis vaccine
99 7. A. l. Production. . . . . . 99 7. A. 2. Test for residual live
virus 99 7. A. 3. Tests for extraneous agents 100 7. A. 3. l. Test for
Mycobacterium tuberculosis . . . . . 100 7. A. 3. 2. Test for extraneous
viruses 100 7. A. 4. Tumourigenicity test. . . . . 100 XII 7 . A. 5.
Potency test . . . . . . . 101 7. A. 6. Test for abnormal toxicity 102
7. B. Live, oral poliomyelitis vaccine 103 7. B. l. Test for extraneous
agents 103 7. B. 2. Test for neurovirulence 105 7. B. 3. Test for
abnormal toxicity 106 8. RABIES VACCINE 106 8. 1. Production 106 8. 2.
Test for residual live virus 107 8. 3. Tests for extraneous
microorganisms 107 8. 3. 1. Test for Mycobacterium tuberculosis 107 8.
3. 2. Tests for extraneous viruses 108 8. 3. 2. 1. In dogs 108 8. 3. 2.
2.