Introduces readers to the state of the art of omics platforms and all
aspects of omics approaches for clinical applications
This book presents different high throughput omics platforms used to
analyze tissue, plasma, and urine. The reader is introduced to state of
the art analytical approaches (sample preparation and instrumentation)
related to proteomics, peptidomics, transcriptomics, and metabolomics.
In addition, the book highlights innovative approaches using
bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of
clinical applications. Particular emphasis is put on integration of data
generated from these different platforms in order to uncover the
molecular landscape of diseases. The relevance of each approach to the
clinical setting is explained and future applications for patient
monitoring or treatment are discussed.
Integration of omics Approaches and Systems Biology for Clinical
Applications presents an overview of state of the art omics techniques.
These methods are employed in order to obtain the comprehensive
molecular profile of biological specimens. In addition, computational
tools are used for organizing and integrating these multi-source data
towards developing molecular models that reflect the pathophysiology of
diseases. Investigation of chronic kidney disease (CKD) and bladder
cancer are used as test cases. These represent multi-factorial, highly
heterogeneous diseases, and are among the most significant health issues
in developed countries with a rapidly aging population. The book
presents novel insights on CKD and bladder cancer obtained by omics data
integration as an example of the application of systems biology in the
clinical setting.
- Describes a range of state of the art omics analytical platforms
- Covers all aspects of the systems biology approach--from sample
preparation to data integration and bioinformatics analysis
- Contains specific examples of omics methods applied in the
investigation of human diseases (Chronic Kidney Disease, Bladder
Cancer)
Integration of omics Approaches and Systems Biology for Clinical
Applications will appeal to a wide spectrum of scientists including
biologists, biotechnologists, biochemists, biophysicists, and
bioinformaticians working on the different molecular platforms. It is
also an excellent text for students interested in these fields.
