Of the myriad of heterocycles known to man, the indole ring stands
foremost for its remarkably versatile chemistry, its enormous range of
biological activities, and its ubiquity in the terrestrial and marine
environments.
The indole ring continues to be discovered in natural products and to be
employed in man-made pharmaceuticals and other materials. Given the
enormous resurgence in indole ring synthesis over the past decade --
highlighted by the power of transition metal catalysis -- this
authoritative guide addresses the need for a comprehensive presentation
of the myriad of methods for constructing the indole ring, from the
ancient to the modern, and from the obscure to the well-known.
Following presentation of the classic indole ring syntheses and many
newer methods, coverage continues with indole ring syntheses via
pyrroles, indolines, oxindoles, isatins, radical and photochemical
reactions, aryne cycloadditions. This extensive volume concludes with
the modern transition metal-catalyzed indole ring syntheses that utilize
copper, palladium, rhodium, gold, ruthenium, platinum, and other metals
to fashion the indole ring
Indole Ring Synthesis is a comprehensive, authoritative and up-to-date
guide to the synthesis of this important heterocycle for organic
chemists, pharmaceutical researchers and those interested in the
chemistry of natural products.
