Well-respected leaders in the field of in vitro neurotoxicology take a
fresh look at their own and other's work, critically and comparatively
analyzing it across experimental systems and toxicants, and synthesizing
essential principles for in vitro neurotoxicity testing. Neurotoxicants
of significance to human health are emphasized, especially those for
which metabolism and dose-responses are well well studied both in vivo
and in vitro: lead, mercury, organophosphorous insecticides,
polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins.
The goal is to set out new concepts and research directions that will
hasten significant improvement in the methods and systems for in vitro
neurotoxicity testing.